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KMID : 1134120210240010097
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Journal of Breast Cancer
2021 Volume.24 No. 1 p.97 ~ p.105
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Palbociclib Plus Fulvestrant in Korean Patients from PALOMA-3 With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2?Negative Advanced Breast Cancer
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Kim Jee-Hyun
Im Seock-Ah
Sim Sung-Hoon
Bananis Eustratios
Huang Xin
Kim Hyun-Seon
Kim Sung-Bae
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Abstract
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In the PALOMA-3 trial, the median progression-free survival (PFS) was longer among patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2?) advanced breast cancer (ABC) treated with palbociclib plus fulvestrant than those treated with placebo plus fulvestrant. This subgroup analysis examined the efficacy and safety of palbociclib among Korean patients enrolled in PALOMA-3 (n = 43 [palbociclib group, n = 24; placebo group, n = 19]). In both groups, > 40% of patients were pre/perimenopausal at enrollment. The median PFS was significantly prolonged with palbociclib vs. placebo (12.3 [95% confidence interval (CI), 9.1?not estimable] vs. 5.4 months [95% CI, 1.9?9.2]; hazard ratio, 0.40 [95% CI, 0.19?0.83]; one-sided p = 0.005), and the confirmed objective response was 21.1% and 11.8%, respectively (odds ratio, 2.0 [95% CI, 0.24?24.8]). Neutropenia was the most common adverse event associated with palbociclib. Overall, palbociclib plus fulvestrant was effective and generally safe among Korean patients with HR+/HER2? ABC, regardless of menopausal status.
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KEYWORD
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Breast neoplasms, Fulvestrant, Korea, Palbociclib, Progression-free survival
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